236 bird species are found there, of which 12 species are endemic: Pink-headed Warbler (Ergaticus versicolor), Brown-backed Solitaire (Myadestes occidentalis), the national bird of Guatemala Resplendent Quetzal (Pharomachrus mocinno), Blue-throated Toucanet (Aulacorhynchus prasinus), Atitlan Grebe (Podylimbus gigas), Azure-rumped Tanager (Tangara cabanisi) and Horned Guan (Oreophasis derbianus). Many migratory birds use Lake Atitlán as a wintering ground: Pied-billed Grebe (Podylimbus podiceps), Ruddy Duck (Oxyura jamaicensis) and American Coot (Fulica Americana).
The unique biodiversity is also reflected in the mammals, from the 141 species are 7 endemic: Guatemalan Deer Mouse (Peromyscus guatemalensis), Black-handed Spider Monkey (Ateles geoffroyi) and Northern Tamandua (Tamandua mexicana). Many of the species mentioned before are listed in the Red Data Book.